研究業績

2017

  • Karasuyama, H., Miyake, K., Yoshikawa, S., and Yamanishi, Y.: Multifaceted roles of basophils in health and disease. J. Allergy Clin. Immunol. in press.
  • Ohta, T., Yoshikawa, S., Tabakawa, Y., Yamaji, K., Ishiwata, K., Shitara, H., Taya C., Oh-hora, M., Kawano, Y., Miyake, K., Yamanishi, Y., Yonekawa, H., Watanabe, N., Kanuka, H., and Karasuyama, H.: Skin CD4+ memory T cells play an essential role in acquired anti-tick immunity through IL-3-mediated basophil recruitment to tick-feeding sites. Front. Immunol. 1348:8, 2017. (PubMed)
  • Dema, B., Lamri, Y., Pellefigues, C., Pacreau, E., Saidoune, F., Bidault, C., Karasuyama, H., Sacré, K., Daugas, E., and Charles, N.: Basophils contribute to pristane-induced Lupus-like nephritis model. Sci. Rep. 11;7(1):7969, 2017 (PubMed)
  • Miyake, K., and Karasuyama, H.: Emerging roles of basophils in allergic inflammation. Allergol. Int. 66(3):382-391, 2017. (PubMed)
  • Bando, T., Fujita, S., Nagano, N., Hayashi, A., Yoshikawa, S., Yamanishi, Y., Minami, M., Tada, H., Kishikawa, K., and Karasuyama, H.: Differential usage of COX-1 and COX-2 in prostaglandin production by mast cells and basophils. Biochem Biophys Rep. 10:82-87, 2017. (PubMed)
  • Yamanishi, Y., Miyake, K., Iki, M., Tsutsui, H., and Karasuyama, H.: Recent advances in understanding basophil-mediated Th2 immune responses. Immunol. Rev. 278:237-245, 2017. (PubMed)
  • Mukai, K., Karasuyama, H., Kabashima, K., Kubo, M., and Galli, S: Differences in the importance of mast cells, basophils, IgE and IgG, versus CD4+ T cells and ILC2 cells, in primary and secondary immunity to Strongyloides venezuelensis. Infect. Immun. 85(5), e00053-17, 2017. (PubMed)
  • Toyama, S., Okada, N., Matsuda, A., Morita, H., Saito, H., Fujisawa, T., Nakae, S., Karasuyama, H., and Matsumoto, K.: Human eosinophils constitutively express a unique serine protease, PRSS33. Allergol. Int. 66(3):463-471, 2017. (PubMed)
  • Tsutsui, H., Yamanishi, Y., Ohtsuka, H., Sato, S., Yoshikawa, S., and Karasuyama, H.: Basophil-specific protease mMCP-8 provokes an inflammatory response in the skin with microvascular hyperpermeability and leukocyte infiltration. J. Biol. Chem. 292(3):1061-1067, 2017. (PubMed)
  • Miyake, K., Shiozawa, N., Nagao, T., Yoshikawa, S., Yamanishi, Y., and Karasuyama, H.: Trogocytosis of peptide-MHC class II complexes from dendritic cells confers antigen-presenting ability on basophils. Proc. Natl. Acad. Sci. USA. 114(5):1111-1116, 2017. (PubMed)

2016

  • Adachi, T., Kakuta, S., Aihara, Y., Kamiya, T., Watanabe, Y., Osakabe, N., Hasato, N., Miyawaki, A., Yoshikawa, S., Usami, T., Karasuyama, H., Kimoto-Nira, H., Hirayama, K., and Tsuji, N.: Visualization of probiotic-mediated Ca2+ signaling in intestinal epithelial cells in vivo. Front. Immunol. 7:601, 2016. (PubMed)
  • Kojima, T., Tsuchiya, K., Ikemizu, S., Yoshikawa, S., Yamanishi, Y., Watanabe, M., and Karasuyama, H.: Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R. Sci. Rep. 6:36457, 2016. (PubMed)
  • Iki, M., Tanaka, K., Deki, H., Fujimaki, M., Sato, S., Yoshikawa, S., Yamanishi, Y., and Karasuyama, H.: Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation in mice. Blood 128: 2909-2918, 2016. (PubMed)
  • Horiguchi, K., Yoshikawa, S., Saito, A., Haddad, S., Ohta, T., Miyake, K., Yamanishi, Y., and Karasuyama, H.: Real-time imaging of mast cell degranulation in vitro and in vivo. Biochem. Biophys. Res. Commun479: 517-522, 2016. (PubMed)
  • Yamanishi, Y., and Karasuyama, H.: Basophil-derived IL-4 plays versatile roles in immunity. Semin. Immunopathol. 38:615–622, 2016. (PubMed)
  • Yamanishi, Y., and Karasuyama, H.: Basophils and mast cells in immunity and inflammation. Semin. Immunopathol. 38:535–537, 2016. (PubMed)
  • Balbino, B., Sibilano, R., Starkl, P., Marichal, T., Gaudenzio, N., Karasuyama, H., Bruhns, P., Tsai, M., Reber, L.L., and Galli, S.J.: Pathways of immediate hypothermia and leukocyte infiltration in an adjuvant-free mouse model of anaphylaxis. J. Allergy Clin. Immunol. 139:584-96, 2016. (PubMed)
  • Baba, T., Tanabe, Y., Yoshikawa, S., Yamanishi, Y., Morishita, S., Komatsu, N., Karasuyama, H., Hirano, A., and Mukaida, N.: MIP-1a/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice. Blood 127(21):2607-17, 2016. (PubMed)
  • Schiechl, G., Hermann, F.J., Rodriguez Gomez, M., Kutzi, S., Schmidbauer, K., Talke, Y., Neumayer, S., Goebel, N., Renner, K ., Brühl, H., Karasuyama, H., Obata-Ninomiya, K., Utpatel, K., Evert, M., Hirt, S.W., Geissler, E.K., Fichtner-Feigl, S., M ack, M.: Basophils trigger fibroblast activation in cardiac allograft fibrosis development. Am. J. Transplant. 16(9):2574-88, 2016. (PubMed)
  • Venturelli, N., Lexmond, W.S., Ohsaki, A., Nurko, S., Karasuyama, H., Fiebiger E., and Oyoshi, M.K.: Allergic skin sensitization promotes eosinophilic esophagitis via the interleukin-33-basophil axis in mice. J. Allergy Clin. Immunol. 138(5):1367-1380, 2016. (PubMed)

2015

  • Yoshikawa, S., Usami, T., Kikuta, J., Ishii M., Sasano, T., Sugiyama, K., Furukawa, T., Nakasho, E., Takayanagi, H., Tedder, T.F., Karasuyama, H., Miyawaki, A., and Adachi, T.: Intravital imaging of Ca2+ signals in lymphocytes of Ca2+ biosensor transgenic mice: indication of autoimmune diseases before the pathological onset. Sci. Rep. 6;6:18738 (PubMed)
  • LiHua, L., Yoshikawa, S., Ohta, T., Horiguchi, K., Kawano, Y., Ohtsu, H., Yamanishi, Y., and Karasuyama, H.: Large particulate allergens can elicit mast cell-mediated anaphylaxis without exit from blood vessels as efficiently as do small soluble allergens. Biochem. Biophys. Res. Commun. 467(1):70-5, 2015. (PubMed)
  • Morita, H., Arae, K., Unno, H., Nambu, A, Oboki, K., Ohno, T., Matsuda, A., Toyama, S., Miyauchi, K., Yamaguchi, S., Narushima, S., Kajiwara, N., Iikura, M., Suto, H., McKenzie, A., Takahashi, T., Karasuyama, H., Okumara, K., Azuma, M., Galli, SJ., Moro, K., Akdis, C., Koyasu, S., Kubo, M., Sudo, K., Saito, H., Matsumoto, K., and Nakae, S.: An interleukin-33-mast cell-interleukin-2 axis suppresses papain-induced allergic airway inflammation by promoting regulatory T cell numbers. Immunity 43, 175–186, 2015. (PubMed)
  • Tsai, S.H., Kinoshita, M., Kusu, T., Kayama, H., Okumura, R., Ikeda, K., Shimada Y., Takeda A., Yoshikawa, S., Obata-Ninomiya, K., Kurashima, Y., Sato, S., Umemoto, E., Kiyono, H., Karasuyama, H., and Takeda, K.: The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells. Immunity 4: 279–293, 2015. (PubMed)

2014

  • Egawa, M., Mukai, K., and Karasuyama, H.: Basophil-derived IL-4 induces the differentiation of inflammatory monocytes into M2-type macrophages to dampen allergic inflammation. Allergic diseases: from mechanisms to cures. pp59-62, 2014.
  • Karasuyama, H.: Basophils. Global Atlas of Allergy pp56-57, 2014. (EAACI web site)
  • Karasuyama H, Yamanishi Y.: Basophils have emerged as a key player in immunity. Curr Opin Immunol. 31:1-7, 2014. (PubMed)
  • Reber, L., Marichal, T., Sokolove, J., Starkl, P., Gaudenzio, N., Iwakura, Y., Karasuyama, H., Schwartz, L.B., Robinson, W.H., Tsai, M., and Galli, S.J.: Mast cell-derived IL-1b contributes to uric acid crystal-induced acute arthritis in mice. Arthritis Rheum. 66:2881-2891, 2014.(PubMed)
  • Morshed, M., Hlushchuk, R., Simon, D., Walls, A.F., Obata-Ninomiya, K., Karasuyama, H., Djonov, V., Eggel, A., Kaufmann, T., Simon, H-U, and Yousefi, S.: NADPH oxidase-independent formation of extracellular DNA traps by basophils. J. Immunol. 192:5314-23, 2014.(PubMed)
  • Bakocevic, N, Claser, C., Yoshikawa, S., Jones, LA., Chew, S., Goh. CC., Malleret, B., Larbi, A., Ginhoux, F., de Lafaille, MC., Karasuyama, H., Renia, L., Ng, LG.: CD41 is a reliable identification and activation marker for murine basophils in the steady-state and during helminth and malarial infections. Eur J Immunol. 44:1823-34, 2014. (PubMed).

2013

  • Kim, S., Karasuyama, H., Lopez, AF., Ouyang, W., Li, X., Le Gros, G., and Min, B.: IL-4 Derived from Non-T Cells Induces Basophil- and IL-3-independent Th2 Immune Responses. Immune Netw. 13:249-56, 2013.(PubMed)
  • Leyva-Castillo, J.M., Hener, P., Michea, P., Karasuyama, H., Chan, S., Soumelis, V., and Li, M.: Skin TSLP initiates Th2 responses through an orchestrated immune cascade. Nat. Commun. 4:2847, 2013.(PubMed)
  • Nei, Y., Obata-Ninomiya, K., Tsutsui, H., Ishiwata, K, Miyasaka, M., Matsumoto, K., Nakae, S., Kanuka, H., Inase, N., and Karasuyama, H.: GATA-1 regulates the generation and function of basophils. Proc. Natl. Acad. Sci. USA. 110: 18620-25, 2013.(PubMed)
  • Obata-Ninomiya, K., Ishiwata, K., Tsutsui, H., Nei, Y., Yoshikawa, S., Kawano, Y., Minegishi, Y., Ohta, N., Watanabe, N., Kanuka, H., and Karasuyama, H.: The skin is an important bulwark of acquired immunity against intestinal helminths. J. Exp. Med. 210: 2583-95, 2013. (PubMed )
  • Anyan, W.K., Seki, T., Kumagai, T., Obata-Ninomiya, K., Furushima-Shimogawara, R., Kwansa-Bentum, B., Akao, N., Bosompem, K. M., Boakye, D.A., Wilson, M.D., Karasuyama, H., and Ohta, N.: Basophil depletion downregulates Schistosoma mansoni egg-induced granuloma formation. Parasitol Int. 62: 508-13, 2013. (PubMed)
  • Torrero, M.N., Morris, C.P., Mitre, B.K., Hübner, M.P., Mueller, E., Karasuyama, H., and Mitre, E.: Basophils help establish protective immunity induced by irradiated larval vaccination for filariasis. Vaccine. 31: 3675-82, 2013. (PubMed)
  • Noti, M., Tait Wojno, E.D., Kim, B.S., Siracusa, M.C., Giacomin, P.R., Nair, M.G., Benitez, A.J., Ruymann, K.R., Muir, A.B., Hill, D.A., Chikwava, K.R., Moghaddam, A.E., Sattentau, Q.J., Alex, A., Zhou, C., Yearley, J.H., Menard-Katcher, P., Kubo, M., Obata-Ninomiya, K., Karasuyama, H., Comeau, M.R., Brown-Whitehorn, T., de Waal Malefyt, R., Sleiman, P.M., Hakonarson, H., Cianferoni, A., Falk, G.W., Wang, M-L., Spergel, J.M., and Artis, D.: Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis. Nat. Med. 19: 1005-1013, 2013. (PubMed)
  • Reber, L.L., Marichal, T., Mukai, K., Roers, A., Hartmann, K., Karasuyama, H., Nadeau, K.C., Tsai, M., and Galli, S.J.: Selective ablation of mast cells or basophils reduces peanut-induced anaphylaxis in mice. J. Allergy Clin. Immunol. in press. (PubMed)
  • Ramadan A, Pham Van L, Machavoine F, Dietrich C, Alkan M,Karasuyama H, Schneider E, Dy M, Thieblemont N.: Activation of basophils by the double-stranded RNA poly(A:U) exacerbates allergic inflammation.  Allergy. 68: 732-8, 2013. (PubMed)
  • Egawa, M., Mukai, K., Yoshikawa, S, Iki, M., Mukaida, N., Kawano, Y., Minegishi, Y., and Karasuyama, H.: Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4. Immunity. 38: 570–580, 2013. (PubMed)
  •  Shiraishi, Y., Jia, Y., Domenico, J., Joetham, A., Karasuyama, H., Takeda, K., and Gelfand, E.W.: Sequential engagement of FceRI on mast cells and basophil histamine H4 receptor and FceRI in allergic rhinitis. J. Immunol. 190: 539-548, 2013. (PubMed)

2012 

  • Kawano, Y., Ouchida, R., Wang, J-Y, Yoshikawa, S. Yamamoto, M., Kitamura, D., and Karasuyama, H.: A novel mechanism for the autonomous termination of pre-B cell receptor expression via induction of lysosomal-associated protein transmembrane 5. Mol. Cell. Biol. 32: 4462-71, 2012. (PubMed)
  • Jin, G., Matsushita, T., Hamaguchi, Y., Le Huu, D., Ishii, T., Hasegawa, M., Obata, K., Karasuyama, H., Takehara, K., and Fu jimoto, M.: Basophils and Mast Cells Play Critical Roles for Leukocyte Recruitment in IgE-Mediated Cutaneous Reverse Passive Arthus Reaction. J. Dermatol. Sci. 67: 181-189, 2012. (PubMed)
  • Mukai, K., BenBarak, M., Tachibana, M., Nishida, K., Karasuyama, H., Taniuchi, I., Galli, SJ.: Critical role of P1-Runx1 in mouse basophil development. Blood. 120: 76-85, 2012. (PubMed)
  • Minegishi Y, Saito M. : Cutaneous Manifestations of Hyper IgE Syndrome. Allergol Int. ;61: 191-196, 2012. (PubMed)
  • Etori, M., Yonekubo, K., Sato, E., Mizukami, K., Hirahara, K., Karasuyama, H., Maeda, H., Yamashita, M.: Melanocortin Receptors 1 and 5 might mediate inhibitory effects of α-melanocyte-stimulating hormone on antigen-induced chronic allergic skin inflammation in IgE transgenic mice. J. Invest. Dermatol. 132(7): 1925-7, 2012. (PubMed)
  • Ogawa, H., Mukai, K., Kawano, Y., Minegishi, Y., and Karasuyama, H.: Th2-inducing cytokines IL-4 and IL-33 synergistically elicit the expression of transmembrane TNF-a on macrophages through the autocrine action of IL-6. Biochem. Biophys. Res. Commun. 420: 114-118, 2012. (PubMed)
  • Ma CS, Avery DT, Chan A, Batten M, Bustamante J, Boisson-Dupuis S, Arkwright PD, Kreins AY, Averbuch D, Engelhard D, Magdorf K, Kilic SS, Minegishi Y, Nonoyama S, French MA, Choo S, Smart JM, Peake J, Wong M, Gray P, Cook MC, Fulcher DA, Casanova JL, Deenick EK, Tangye SG.: Functional STAT3 deficiency compromises the generation of human T follicular helper cells. Blood. 119(17): 3997-4008. 2012. (PubMed)
  • Sawaguchi M, Tanaka S, Nakatani Y, Harada Y, Mukai K, Matsunaga Y, Ishiwata K, Oboki K, Kambayashi T, Watanabe N, Karasuyama H,Nakae S, Inoue H, Kubo M. Role of Mast Cells and Basophils in IgE Responses and in Allergic Airway Hyperresponsiveness.J Immunol 188: 1809-18, 2012. (PubMed)

2011

  • Watarai A, Niiyama S, Morita M, Bando Y, Minegishi Y, Katsuoka K.: Hyper IgE syndrome diagnosed in early infancy by gene analysis of STAT3 mutation. Eur J Dermatol. 21(2): 254-255, 2011. (PubMed)
  • Minegishi Y, Saito M. Molecular mechanisms of the immunological abnormalities in hyper-IgE syndrome. Ann N Y AcadSci1246: 34-40, 2011. (PubMed)
  • Porcherie, A., Mathieu, C., Peronet, R., Schneider, E., Claver, J., Commere, P-H., Kiefer-Biasizzo, H., Karasuyama, H ., Milon, G., Dy, M., Kinet, J-P., Louis, J., Blank, U., and Mecheri, S.: Critical role of the neutrophil-associated high-affinity receptor for IgE in the pathogenesis of experimental cereberal malaria. J. Exp. Med .208: 2225-2236, 2011. (PubMed)
  • Yamagishi, H., Mochizuki, Y., Hamakubo, T., Obata, K., Ugajin, T., Sato, S., Kawano, Y., Minegishi, Y., and Karasuyama, H .: Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner. Biochem. Biophys. Res. Commun .415: 709-713, 2011. (PubMed)
  • Karasuyama, H ., Obata, K., Wada, T., Tsujimura, Y., and Mukai, K.: Newly appreciated roles for basophils in allergy and protective immunity. Allergy 66: 1133-1141, 2011. (PubMed)
  • Nishikado, H., Mukai, K., Kawano, Y., Minegishi, Y., and Karasuyama, H .: NK cell-depleting anti-asialo GM1 Ab exhibits a lethal ‘off-target' effect on basophils in vivo J. Immunol .186: 5766-5771, 2011. (PubMed)
  • Ishikawa, Y., Kobayashi, K., Yamamoto, M., Nakata, K., Takagawa, T., Funada, Y., Kotani, Y., Karasuyama, H ., Yoshida, M., and Nishimuar, Y.: Antigen-specific IgG ameliorates allergic airway inflammation via Fcγ receptor IIB on dendritic cells. Respir. Res . 12: 42, 2011. (PubMed)
  • Jonsson, F., Mancardi, D.A., Kita, Y., Karasuyama, H ., Iannascoli, B., Van Rooijen, N., Shimizu , T., Daeron, M, and Bruhns, P.: Mouse and human neutrophils induce anaphylaxis. J. Clin. Invest .121: 1484-1496, 2011. (PubMed)
  • Saito, M., Nagasawa, M., Takada, H., Hara, T., Tsuchiya, S., Agematsu, K., Yamada, M., Kawamura, N., Ariga, T., Tsuge, I., Nonoyama, S., Karasuyama, H ., and Minegishi, Y.: Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells. J. Exp. Med .208: 235-249, 2011. (PubMed)
  • Karasuyama, H., Wada, T., Yoshikawa, S., and Obata, K.: Emerging roles of basophils in protective immunity against parasites. Trends Immunol .32: 125-130, 2011. (PubMed)
  • Karasuyama, H., Mukai, K., Obata, K., Tsujimura, Y., and Wada, T.: Nonredundant roles of basophils in immunity. Annu. Rev. Immunol . 29: 45-69, 2011. (PubMed)

2010

  • Karasuyama, H., Mukai, K., Obata, K., Tsujimura, Y., Kawano, Y., and Minegishi, Y.: Nonredundant roles for basophils in immediate- and delayed-onset allergic reactions. The Open Allergy Journal .3: 73-80, 2010. (Online publication)
  • Torrero, M.N., Hubner, M.P., Larson, D., Karasuyama, H., and Mitre, E.: Basophils amplify type 2 immune responses, but do not serve a protective role, during chronic infection of mice with the filarial nematodeLitomosoidessigmodontis J. Immunol .185: 7426-7434, 2010. (PubMed)
  • Ishikawa, R., Tsujimura, Y., Obata, K., Kawano, Y., Minegishi, Y., and Karasuyama, H.: IgG-mediated systemic anaphylaxis to protein antigen can be induced even under conditions of limited amounts of antibody and antigen. Biochem. Biophys. Res. Commun .402: 742-746, 2010. (PubMed).
  • Wada, T., Ishiwata, K., Koseki, H., Ishikura, T., Ugajin, T., Ohnuma, N., Obata, K., Ishikawa, R., Yoshikawa, S., Mukai, K., Kawano, Y., Minegishi, Y., Yokozeki, H., Watanabe, N., and Karasuyama, H.: Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J. Clin. Invest .120: 2867-2875, 2010. (PubMed).
  • Karasuyama, H., Tsujimura Y., Obata, K., Mukai, K., and Minegishi Y.: Basophils and mast cells play distinct roles in acute and chronic allergic reactions. Environmental and genetic factors in allergy and clinical immunology . (Eds.: van Ree, R., Ring, J., and Marone, G) pp63-65, 2010.
  • Matsushima, Y., Kikkawa, Y., Takada, T, Matsuoka, K., Seki, Y., Yoshida, H., Minegishi, Y., Karasuyama, H ., and Yonekawa, H.: An atopic dermatitis-like skin disease with hyper-IgEemia develops in mice carrying a spontaneous recessive point mutation in the Traf3ip2 (Act1/CIKS) gene. J. Immunol .185: 2340-2349, 2010 (PubMed).
  • Anyan, W.K., Kumagai, T., Simogawara, R.F., Seki, T., Akao, N, Obata K., Kwansa-Bentum, B., Bosompem, K.M., Boakye, D.A., Wilson, M.D., Karasuyama, H., and Ohta, N.: Schistosoma eggs have a direct role in the induction of basophils capable of a high level of IL-4 production: Comparative study of single- and bisexual infection of Schistosomamansoni in vivo. Trop. Med. Health 38: 13-22, 2010.
  • Karasuyama, H ., Tsujimura, Y., Obata, K., and Mukai, K.: Role for basophils in systemic anaphylaxis.Chem. Immunol. Allergy .95: 85-97, 2010. (PubMed).
  • Nakata, K., Kobayashi, K., Ishikawa, Y., Yamamoto, M., Funada, Y., Kotani, Y., Blumberg, R.S., Karasuyama, H., Yoshida, M., and Yoshihiro Nishimura.: The transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dependent manner. Biochem. Biophys. Res. Commun .395:238-243, 2010. (PubMed).

2009

  • Ugajin, T., Kojima, T., Mukai, K., Obata K., Kawano, Y., Minegishi, Y., Eishi Y., Yokozeki, H., and Karasuyama, H.: Basophils preferentially express mouse mast cell protease 11 among the mast cell tryptase family in contrast to mast cells. J. Leukoc. Biol .86: 1417-1425, 2009. (PubMed).
  • Takai, T., and Karasuyama, H.: The study of allergy by Japanese researchers: a historical perspective. Int. Immunol .21: 1311-1316, 2009. (PubMed).
  • Minegishi, Y.: Hyper-IgE syndrome. Curr. Opin. Immunol .21: 487-492, 2009. (PubMed).
  • Minegishi, Y., Saito, M., Nagasawa, M., Takada, H., Hara, T., Tsuchiya, S., Agematsu, K., Yamada, M., Kawamura, N., Ariga, T., Tsuge, I., and Karasuyama, H .: Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome. J. Exp. Med .206: 1291-1301, 2009. (PubMed).
  • Belkina N. V., Lie, Y., Hao J-J.,Karasuyama, H. and Shaw, S.: LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation. Proc. Natl. Acad. Sci. USA 106: 4707-4712, 2009. (PubMed).
  • Mukai, K., Obata, K., Tsujimura, Y. and Karasuyama, H.: New insights into the roles for basophils in acute and chronic allergy. Allergol. Int .58: 11-19, 2009. (PubMed).
  • Khodoun, M., Strait, R., Orekov, T., Hogan, S., Karasuyama, H ., Herbert, D. R., Kohl, J. and Finkelman, F. D. : Peanuts can contribute to anaphylactic shock by activating complement. J. Allergy Clin. Immunol .58: 11-19, 2009. (PubMed).
  • Minegishi Y. and Karasuyama, H.: Defects in Jak-STAT-mediated cytokine signals cause hyper-IgE syndrome: lessons from a primary human immunodeficiency . Int. Immunol. 21: 105-112, 2009. (PubMed).
  • Hida, S., Yamasaki, S., Sakamoto, Y., Takamoto, M., Obata, K., Takai, T., Karasuyama, H., Sugane, K., Saito, T. and Taki, S.: Fc receptor g -chain, a constitutive component of the interleukin 3 receptor is required for interleukin 3-induced interleukin 4. Nat. Immunol. 10: 214-222, 2009. (PubMed).
  • Karasuyama, H., Mukai, K., Tsujimura, Y. and Obata, K.: Newly-discovered roles for basophils: a neglected minority gains new respect. Nat. Rev. Immunol . 9: 9-13, 2009 (PubMed).
  • Yoshikawa, S., Kawano, Y., Minegishi, Y. and Karasuyama, H.: The skewed heavy-chain repertoire in peritoneal B-1 cells is predetermined by the selection via pre-B cell receptor during B cell ontogeny in the fetal liver. Int. Immunol . 21: 43-52, 2009. (PubMed) .

2008

  • Watanabe, M., Satoh, T., Yamamoto, Y., Kanai, Y., Karasuyama, H. and Yokozeki, H.: Overproduction of IgE induces macrophage-derived chemokine (CCL22) secretion from basophils. J. Immunol. 181: 5653-5659, 2008 (PubMed).
  • Takada, T., Shitara, H., Matsuoka, K., Kojima, E., Ishii, R., Kikkawa, Y., Karasuyama, H ., Kohno, K. and Yonekawa, H.: A novel hairless mouse model on an atopic dermatitis-prone genetic background generated by receptor-mediated transgenesis. Transgenic Res 17(6): 1155-1162, 2008 (PubMed).
  • Minegishi, Y. and Karasuyama, H .: Genetic origins of hyper-IgE syndrome. Curr. Allergy Asthma Rep .8(5): 386-91, 2008 (PubMed).
  • Yasuda, T., Sanjo, H., Pages, G., Kawano, Y., Karasuyama, H ., Pouyssegur, J., Ogata, M. and Kurosaki, T. Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity 28: 499-508, 2008 (PubMed).
  • Tsujimura, Y., Obata, K., Mukai, K., Shindou, H., Yoshida, M., Nishikado, H., Kawano, Y., Minegishi, Y., Shimizu, T. and Karasuyama, H .: Basophils play a pivotal role in immunoglobulin G- but not immunoglobulin E-mediated systemic anaphylaxis. Immunity 28: 581-589, 2008 (PubMed).

2007

  • Minegishi, Y. and Karasuyama, H.: Hyperimmunoglobulin E syndrome and tyrosine kinasae 2 deficiency.Curr. Opin. Allergy ClinImmunol .7: 506-509, 2007 (PubMed).
  • Kojima, T., Obata, K., Mukai, K., Sato, S., Takai , T. , Minegishi, Y., and Karasuyama, H .: Mast cells and basophils are selectively activated in vitro and in vivo through CD200R3 in an IgE-independent manner.J. Immunol. 179: 7093-7100, 2007 (PubMed).
  • Minegishi, Y., Saito, M., Tsuchiya, S., Tsuge, I., Takada, H., Hara T., Kawamura, N., Ariga, T., Pasic, S., Stojkovic, O., Metin, A., and Karasuyama, H .: Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Nature 448: 1058-1062, 2007 (PubMed).
  • Obata, K., Mukai, K., Tsujimura, Y., Ishiwata, K., Kawano, Y., Minegishi, Y., Watanabe, N., and Karasuyama, H.: Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood 110: 913-920, 2007. (PubMed)

2006

  • Minegishi, Y., Saito, M., Morio, T., Watanabe, K., Agematsu, K., Tsuchiya, S., Takada, H., Hara, T., Kawamura, N., Ariga, T., Kaneko, H., Kondo, N., Tsuge, T., Yachie, A., Sakiyama, Y., Iwata, T., Bessho, F., Ohishi, T., Joh, K., Imai, K., Kogawa, K., Shinohara, M., Fujieda, M., Wakiguchi, H., Pasic, S., Abinun, M., Ochs, H., D., Renner, E., D., Jansson, A., Belohradsky, B., H., Metin, A., Shimizu, N., Mizutani, S., Miyawaki, T., Nonoyama, S., and Karasuyama, H.: Human Tyk2 deficiency reveals requisite roles of Tyk2 in multiple cytokine signals involved in innate and acquired immunity.Immunity 25: 745-755, 2006 (PubMed)
  • Ochiai, K., Katoh, Y., Ikura, T., Hoshikawa, Y., Noda, T., Karasuyama, H ., Tashiro, S., Muto, A. and Igarashi, K.: Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells. J. Biol. Chem. 15; 281(50): 38226-38234, 2006 (PubMed)
  • Yamamoto, M., Hayashi, K., Nojima, T., Matsuzaki, Y., Kawano, Y., Karasuyama, H., Goitsuka, R., and Kitamura D.: BASH-novel PKC-Raf-1 pathway of pre-BCR signaling induces k gene rearrangement.Blood108: 2703-2711, 2006 (PubMed)
  • Kawano, Y., Yoshikawa, S., Minegishi, Y., and Karasuyama, H.: PreB cell receptor assesses the quality of IgH chains and tunes the preB cell repertoire by delivering differential signals. J. Immunol. 177: 2242-2249, 2006 (PubMed)
  • Kubota, T., Mukai, K., Minegishi, Y., and Karasuyama, H.: Different stabilities of the structurally-related receptors for IgE and IgG on the cell surface are determined by length of the stalk region in their α chains. J. Immunol. 176: 7008-7014, 2006 (PubMed)

2005

  • Mukai, K., Matsuoka, K., Taya, C., Suzuki, H., Yokozeki, H., Nishioka, K., Hirokawa, K., Etori, M., Yamashita, M., Kubota, T., Minegishi, Y., Yonekawa, H., and Karasuyama, H.: Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells.Immunity 23: 191-202, 2005 (PubMed)
  • Jimi, E., Phillips, R. J., Rincon, M., Voll, R., Karasuyama, H., Flavell, R., and Ghosh, S.: Activation of NFk-B promotes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells.Int. Immunol. 17: 815-825, 2005 (PubMed)
  • Kawano, Y., Yoshikawa, S., Minegishi, Y., and Karasuyama, H.: Selection of stereotyped VH81X-mH chains via preB cell receptor early in ontogeny and their conservation in adults by marginal zone B cells.Int. Immunol. 17: 857-867, 2005 (PubMed)
  • Toyama-Sorimachi N, Omatsu Y, Onoda A, Tsujimura Y, Iyoda T, Kikuchi-Maki A, Sorimachi H, Dohi T, Taki S, Inaba K, Karasuyama H.: Inhibitory NK Receptor Ly49Q Is Expressed on Subsets of Dendritic Cells in a Cellular Maturation- and Cytokine Stimulation-Dependent Manner.J. Immunol. 174:4621-9, 2005 (PubMed)
  • Omata N, Ohshima Y, Yasutomi M, Yamada A, Karasuyama H, Mayumi M.: Ovalbumin-specific IgE modulates ovalbumin-specific T-cell response after repetitive oral antigen administration.J. Allergy Clin. Immunol. 115: 822-7, 2005 (PubMed)
  • Shinohara H, Inoue A, Toyama-Sorimachi N, Nagai Y, Yasuda T, Suzuki H, Horai R, Iwakura Y, Yamamoto T, Karasuyama H, Miyake K, Yamanashi Y.: Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling.J. Exp. Med. 201: 333-9, 2005 (PubMed)

2004

  • Taguchi T, Kiyokawa N, Takenouch H, Matsui J, Tang WR, Nakajima H, Suzuki K, Shiozawa Y, Saito M, Katagiri YU, Takahashi T, Karasuyama H, Matsuo Y, Okita H, Fujimoto J.: Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells.Immunology 112: 575-582, 2004 (PubMed)
  • Kiyokawa N, Sekino T, Matsui T, Takenouchi H, Mimori K, Tang WR, Matsui J, Taguchi T, Katagiri YU, Okita H, Matsuo Y, Karasuyama H, Fujimoto J.: Diagnostic importance of CD179a/b as markers of precursor B-cell lymphoblastic lymphoma. Mod. Pathol. 17: 423-9, 2004 (PubMed)
  • Maezawa, Y., Nakajima, H., Seto, Y., Suto, A., Kumano, K., Kubo, S., Karasuyama, H., Saito, Y., Iwamoto, I.: IgE-dependent enhancement of Th2 cell-mediated allergic inflammation in the airways. Clin. Exp. Immunol. 135: 12-18, 2004 (PubMed)
  • Toyama-Sorimachi, N., Tsujimura, Y., Maruya,M., Onoda, A., Kubota, T., Koyasu, S., Inaba, K. and Karasuyama, H.: Ly49Q, a novel member of Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture.Proc. Natl. Acad. Sci. USA. 101: 1016-1021, 2004 (PubMed)

2003

  • Terauchi, M., Koi, H., Hayano, C., Toyama-Sorimachi, N., Karasuyama, H., Yamanashi, Y., Aso, T. and Shirakata, M.: Placental extravillouscytotrophoblasts persistently express class I major histocompatibility complex molecules after human cyotomegalovirus infection. J. Virol. 77: 8187-8195, 2003 (PubMed)
  • Kawashima, I., Yoshida, Y., Taya, C., Shitara, H., Yonekawa, H., Karasuyama, H., Tada, N., Furukawa, K., Tai, T.: Expansion of natural killer cells in mice transgenic for IgM antibody to ganglioside GD2: demonstration of prolonged survival after challenge with syngeneic tumor cells. Int. J. Oncol. 23: 381-388, 2003 (PubMed)
  • Maezawa, Y., Nakajima, H., Kumano, K., Kubo, S., Karasuyama, H., Iwamoto, I.: Role of IgE in Th2 cell-mediated allergic airway inflammation. Int. Arch. Allergy Immunol..131 Suppl 1: 2-6, 2003. (PubMed)
  • Saijo, K., Schmedt, C., Su, I-h.,Karasuyama, H., Lowell, C.A., Reth, M., Adachi, T., Patke, A., Santana, A. and Tarakhovsky, A.: Essential role of Src-family protein tyrosine kinases in NF-kB activation during B cell development. Nature Immunol. 4: 274-279, 2003. (PubMed)
  • Tsuchiya, K., Kawano, Y., Kojima, T., Nagata, K., Takao, T., Okada, M., Shinohara, H., Maki, K., Toyama-Sorimachi, N., Miyasaka, N., Watanabe, M. and Karasuyama, H.: Molecular cloning and characterization of TPP36 and its isoform TPP32, novel substrates of Abl tyrosine kinase. FEBS lett. 537: 203-209, 2003. (PubMed)
  • Kubo, S., Nakayama, T., Matsuoka, K., Yonekawa, H., Karasuyama, H.: Long-term maintenance of IgE-mediated memory in mast cells in the absence of detectable serum IgE. J. Immunol. 170: 775-780, 2003. (PubMed)
  • Sato, E., Hirahara, K., Wada, Y., Yoshitomi, T., Azuma, T., Matsuoka, K., Kubo, Taya, C., Yonekawa, H., Karasuyama, H. and Shiraishi, A.: Chronic inflammation in skin can be induced in IgE transgenic mice by a single challenge of multivalent antigen. J. Allergy Clin. Immunol. 111: 143-148, 2003. (PubMed)
  • Taguchi, T., Kiyokawa, N., Mimori, K., Suzuki, T., Sekino, T., Nakajima, H., Saito, M., Katagiri, Y., Matsuo, N., Matsuo, Y., Karasuyama, H. and Fujimoto, J.: Pre-BCR-mediated signal inhibits CD24-induced apoptosis in human pre-B cells. J. Immunol. 170: 252-260, 2003.(PubMed)

2002

  • Wang, J.-W., Howson, J. M., Ghansah, T., Desponts, C., Ninos, J. M., May, S. L., Nguyen, K. H. T., Toyama-Sorimachi, N. and Kerr, W. G.: Influence of SHIP on the NK repertoire and allogeneic bone marrow transplantation. Science 295: 2094-2097, 2002. (PubMed)
  • Wang, Y-H., Stephan, R. P., Scheffold, A., Kunkel, D., Karasuyama, H., Radbruch, A. and Cooper M. D.: Differential surrogate light chain expression governs B cell differentiation. Blood 99:2 459-2467, 2002. (PubMed)

2001

  • Stephan, R. P., Elgavish, E., Karasuyama, H., Kubagawa, H., Cooper, M. D.: Analysis of VpreB expression during B lineage differentiation in lambda5-deficient mice. J. Immunol. 167: 3734-3739, 2001. (PubMed)
  • Kubo, S., Matsuoka, K., Taya, C., Kitamura, F., Takai, T., Yonekawa, H. and Karasuyama, H.: Drastic up-regulation of high affinity IgE receptor on mast cells is induced by IgE binding through stabilization and accumulation of the receptor on the cell surface. J. Immunol. 167: 3427-34, 2001. (PubMed)
  • Kinoshita, T., Nagata, K., Sorimachi, N., Karasuyama, H., Sekiguchi, T., Miyajima,A.: Oncostatin M suppresses generation of lymphoid progenitors in fetal liver by inhibiting the hepatic microenvironment.Exp. Hematol. 299: 1091-7, 2001. (PubMed)
  • Agematsu K, Nagumo H, Hokibara S, Mori T, Wada T, Yachie A, Kanegane H, Miyawaki T, Sugita K, Karasuyama H, Komiyama A.: Complete arrest from pro- to pre-B cells in a case of B cell-negative severe combined immunodeficiency (SCID) without recombinase activating gene (RAG) mutations. Clin. Exp. Immunol. 124: 461-464, 2001. (PubMed)
  • Kouro, T., Nagata, K., Takaki, S., Karasuyama, H. and Takatsu, K.: Bruton's tyrosine kinase (Btk) is required for signaling the CD79b-mediated pro-B to pre-B cell transition. Int. Immunol. 13: 485-493, 2001. (PubMed)
  • Toyama-Sorimachi, N., Taguchi, Y., Yagita, H., Kitamura, F., Kawasaki, A., Koyasu, S. and Karasuyama, H.: Mouse CD94 participates in Qa-1-mediated self recognition by NK cells and delivers inhibitory signals independent of Ly-49. J. Immunol. 166: 3771-9, 2001. (PubMed)
  • Kohara, Y., Tanabe, K., Matsuoka, K., Kanda, N., Matsuda, H., Karasuyama, H. and Yonekawa, H.: A major determinant QTL responsible for atopic dermatitis-like skin lesions in NC/Nga mice is located on chromosome 9. Immunogenetics 53: 15-21, 2001. (PubMed)
  • Fujimoto T, Kawashima H, Tanaka T, Hirose M, Toyama-Sorimachi N, Matsuzawa Y, Miyasaka M.: CD44 binds a chondroitin sulfate proteoglycan, aggrecan. Int. Immunol. 13: 359-66, 2001. (PubMed)
  • Kubo, S. Matsuoka, K, Taya, C, Kitamura, F, Yonekawa, H. and Karasuyama, H.: IgE stabilizes its high affinity receptor (Fc?RI) on mast cells in vitro and ex vivo: The mechanism of IgE-mediated Fc?RI up-regulation and its physiological meaning. In Activating and inhibitory immunoglobulin-like receptors.Eds. Cooper M.D., Takai, T, Ravetch, J.V. Springer-Verlag Tokyo, pp183-188, 2001.
  • Maki, K., Nagata, K, Kitamura, F., Takemori, T. and Karasuyama, H.: The preBCR signaling through Ig?regulates locus accessibility for ordered immunoglobulin gene rearrangements. In Activating and inhibitory immunoglobulin-like receptors: Eds. Cooper, M. D., Takai, T., Ravetch, J. V., Springer-Verlag, Tokyo, pp153-158, 2001.
  • Toyama-Sorimachi, N., Taguchi, Y., Yagita, H., Kitamura, F., Kawasaki, A., Koyasu, S. and Karasuyama, H.: Functional characterization of mouse CD94 by using a novel monoclonal antibody. In Activating and inhibitory immunoglobulin-like receptors. Eds. Cooper, M. D., Takai, T., Ravetch, J. V., Springer-Verlag, Tokyo, pp85-89, 2001.
  • Minegishi, Y., Conley, M.E. Negative selection at the pre-BCR checkpoint elicited by human ? heavy chain with unusual CDR3 regions. Immunity 14, 631-641, 2001. (PubMed)
  • Wang, D., Boylin, E.C., Minegishi, Y., Wen, R., Smith, C.I., Ihle, J.N., Conley, M.E. Variations in the human phospholipase Cgamma2 gene in patients with B-cell defects of unknown etiology. Immunogenetics53, 550-556, 2001. (PubMed)
  • Rapalus L., Minegishi Y., Lavoie A., Cunningham-Rundles C., Conley M.E. Analysis of SWAP-70 as a Candidate Gene for Non-X-Linked Hyper IgM Syndrome and Common Variable Immunodeficiency. Clin. Immunol. 101: 270-275, 2001. (PubMed)

2000~

  • Ohnishi, K., Melchers, F., Karasuyama, H. and Shimizu, T.: The identification of a non-classical cadherin expressed during B cell development and its interaction with surrogate light chain. J. Biol. Chem. 275: 31134-44, 2000. (PubMed)
  • Ellinger-Ziegelbauer, H., Karasuyama, H.,Yamada, E., Tsujikawa, K., Todokoro, K. and Nishida, E.: Ste20-like kinase (SLK), a regulatory kinase for polo-like kinase (Plk) during the G2/M transition in somatic cells. Genes Cells 5: 491-498, 2000. (PubMed)
  • Nagaoka, H., Takahashi, Y., Hayashi, R., Nakamura, T., Ishii, K., Matsuda, J., Ogura, A., Shirakata, Y., Karasuyama, H., Sudo, T., Nishikawa, S., Tsubata, T., Mizuochi, T., Asano, T., Sakano, H. and Takemori, T.: Ras mediates effector pathways responsible for pre-B cell survival, which is essential for the developmental progression to the late pre-B cell stage. J. Exp. Med. 192: 171-182, 2000. (PubMed)
  • Nomura, K., Kanegane, H., Karasuyama, H., Tsukada, S., Agematsu, K., Murakami, G., Sakazume, S., Sako, M., Tanaka, R., Kuniya, Y., Komeno, T., Ishihara, S., Hayashi, K., Kishimoto, T. and Miyawaki, T.: Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway. Blood 96: 610-617, 2000. (PubMed)
  • Tagawa, K., Taya, C., Hayashi, Y., Nakagawa, M., Ono, Y., Fukuda, R., Karasuyama, H., Toyama-Sorimachi, N., Katsui, Y., Hata, S., Ishiura, S., Nonaka, I., Seyama, Y., Arahata, K., Yonekawa, H., Sorimachi, H. and Suzuki, K.: Myopathy phenotype of transgenic mice expressing active site-mutated inactive p94 skeletal muscle-specific calpain, the gene product responsible for limb girdle muscular dystrophy type 2A. Hum. Mol. Genet. 9: 1393-1402, 2000. (PubMed)
  • Donohoe, M. E., Beck-Engeser, G. B., Lonberg, N., Karasuyama, H., Riley, R. L., Jak, H-M., and Blomberg, B. B.: Transgenic human ?5 rescues the murine ?5 nullizygous phenotype. J. Immunol. 164: 5269-5276, 2000. (PubMed)
  • Maki, K., Nagata, K., Kitamura, F., Takemori, T. and Karasuyama, H.: Immunoglobulin b signaling regulates locus accessibility for ordered Ig gene rearrangements. J. Exp. Med. 191: 1333-1340, 2000. (PubMed)
  • Nagata, K., Tsuji, T., Matsushima, K., Hanai, N. and Irimura, T.: Redistribution of P-Selectinconunter-ligands is prerequisite to superoxide anion production and release by human neutrophils. Int. Immunol.12:487-492, 2000. (PubMed)
  • Endo, J., Toyama-Sorimachi, N., Taya, C., Kuramochi-Miyagawa, S., Nagata, K., Kuida, K., Takashi, T., Yonekawa, H., Yoshizawa, Y., Miyasaka, N. and Karasuyama, H.: Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytes. FEBS lett. 468: 234-238, 2000. (PubMed)
  • Minegishi, Y., Lavoie, A., Cunningham-Rundles, C., Bedard, P.M., Hebert, J., Louise, C., Dan, K., Sedlak, D., Buckley, R.H., Fischer, A., Durandy, A., Conley, M.E. Mutations in AID in patients with Hyper IgM syndrome. Clin. Immunol..97, 203-210, 2000. (PubMed)
  • Conley, M.E., Rohrer, J., Minegishi, Y. X-linked agammaglobulinemia. Clin. Rev. Allergy. Immunol. 19, 183-204, 2000. (PubMed)
  • Conley, M.E., Rohrer, J., Rapalus, L., Boylin, E., Minegishi, Y. Defects in B cell development: Comparing the consequences of abnormalities in pre-BCR signaling in the human and the mouse. Immunol. Rev. 178, 75-90, 2000. (PubMed)
  • Bosma, G. C., Chang, Y., Karasuyama, H. and Bosma, M. J.: Differential effect of an immunoglobulin ?transgene on development of pre-B cells in fetal and adult scid mice. Proc. Natl. Acad. Sci. USA. 96: 11952-11957, 1999. (PubMed)
  • Miyazaki, T., Kato, I., Takeshita, S., Karasuyama, H. and Kudo, A.: ?5 is required for rearrangement of the Ig ? light chain gene in pro-B cell lines. Int. Immunol. 11: 1195-1202, 1999. (PubMed)
  • Rolink, A., Andersson, J., Ghia, P., Grawunder, U., Kalberer, C., Karasuyama, H., Oka, Y., ten Boekel, E., Winkler, T. H. and Melchers, F.: Molecular mechanisms guiding B cell development. In Primary immunodeficiency diseases (eds. Ochs, H. D., Smith, E. I. E. and Puck, J. M.) pp.56-65. Oxford University Press, New York, 1999.
  • Matsuoka, K., Taya, C., Kubo, S., Toyama-Sorimachi, N., Kitamura, F., Ra, C., Yonekawa, H. and Karasuyama, H.: Establishment of antigen-specific IgE transgenic mice to study pathological and immunobiological roles of IgE in vivoInt. Immunol. 11: 987-994, 1999. (PubMed)
  • Kuramochi, S., Matsuda, Y., Okamoto, M., Kitamura, F., Yonekawa, H. and Karasuyama, H.: Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase and comparative chromosomal mapping of the human, mouse and rat homologues. Immunogenetics 49: 369-375, 1999. (PubMed)
  • Ishiwatari-Hayasaka, H., Osawa, T., Fujimoto, T., Hirama, T., Toyama-Sorimachi, N. and Miyasaka, M. : Requirements for signal delivery through CD44.; Analysis using CD44-Fas chimeric proteins. J. Immunol.163: 1258-1264, 1999. (PubMed)
  • Ye, S. K., Maki, K., Kitamura, T., Sunaga, S., Akashi, K., Domen, J., Weissman, I. L., Honjo, T. and Ikuta, K. : Induction of germline transcription in the TCR? locus by Stat5; implications for accessibility control by the IL-7 receptor. Immunity 11: 213-223, 1999. (PubMed)
  • Yoshida, H., Honda, K., Shinkura, R., Adachi, S., Nishikawa, S., Maki, K., Ikuta, K. and Nishikawa, S.I.: IL-7 receptor ?+ CD3- cells in the embryonic intestine induces the organizing center of Peyerユs patches. Int. Immunol. 11: 643-655, 1999. (PubMed)
  • Abe, K., Matsuoka, K., Inoue, N., Taga, M. and Kato, T.: Messenger RNA of neuronal nitric oxide synthase is expressed and possibly functions in mouse oocytes and embryos during preimplantation development. Biomed. Res. 20: 61-65, 1999.
  • Yamaguchi, M., Machida, H., Korenaga, R., Toyama-Sorimachi, N., Ando, J., Miyasaka, M., Matsumoto, T., Nakano, H., Kumada, K., Takeda, M.: The effect of flow on the neutrophil-mediated Ca2+ responses in human vascular endothelial cells stimulated by endotoxin. Surg. Today 29: 966-969, 1999. (PubMed)
  • Rohrer, J., Minegishi, Y., Richter, D., Eguiguren, J., Conley, M.E. Unusual mutations in Btk: An insertion a duplication, an inversion, and four large deletions. Clin. Immunol. 90, 28-37, 1999. (PubMed)
  • Minegishi, Y., Hendershot, L. M., Conley, M. E. Novel mechanisms control the folding and assembly of?5/14.1 and VpreB to produce an intact surrogate light chain. Proc. Natl. Acad. Sci. USA.. 96. 3041-3046. 1999. (PubMed)
  • Minegishi, Y., Coustan-Smith, E., Rapalus, L. Ersoy, F., Campana, D., Conley, M.E. Mutations in Ig? (CD79a) result in a complete block in B-cell development. J. Clin. Invest. 104, 1115-1121, 1999. (PubMed)
  • Conley, M.E., Rapalus, L., Boylin, E.C., Rohrer, J., Minegishi, Y. Gene conversion events contribute to the polymorphic variation of the surrogate light chain gene ?5/14.1. Clin. Immunol. 93, 162-167, 1999. (PubMed)
  • Minegishi, Y., Rohrer, J., Coustan-Smith, E., Lederman, H.M., Pappu, R., Campana, D., Chan, A.C., Conley, M.E. An essential role for BLNK in human B cell development. Science, 286, 1954-1957, 1999. (PubMed)
  • Minegishi, Y., Rohrer, J., Conley, M.E. Defects in B cell development-Recent progress in diagnosis and therapy. Curr. Opin. Pediatr. 11, 528-532, 1999.. (PubMed)
  • Tsuganezawa, K., Kiyokawa, N., Matsuo, Y., Kitamura, F., Toyama-Sorimachi, N., Kuida, K., Fujimoto, J. and Karasuyama, H.: Flow cytometric diagnosis of the cell lineage and developmental stage of acute lymphoblastic leukemia by novel monoclonal antibodies specific to human preB cell receptor. Blood 92: 4317-4324, 1998. (PubMed)
  • Muto, A., Hoshino, H., Madisen, L., Yanai, N., Obinata, M., Karasuyama, H., Hayashi, N., Nakauchi, H., Yamamoto, M, Groudine, M. and Igarashi, K.: Identification of Bach2 as a B cell-specific partner for small Maf proteins that negatively regulates the immunoglobulin heavy chain gene 3ユ enhancer. EMBO J. 17: 5734-5743, 1998. (PubMed)
  • Kuida, K., Haydar, T. F., Kuan, C-Y.,Gu, Y., Taya, C., Karasuyama, H., Su, M. S.-S., Rakic, P. and Flavell, R. A.: Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell94: 325-337, 1998. (PubMed)
  • Meffre, E., Papavasiliou, F., Cohen, P., de Bouteiller, O., Bell, D., Karasuyama, H., Schiff, C., Banchereau, J., Liu, Y. J. and Nussenzweig, M. C.: Antigen receptor engagement turns off the V(D)J recombination machinery in human tonsil B cells. J. Exp. Med. 188: 765-772, 1998. (PubMed)
  • Karasuyama, H. and Takatsu, K.: B cell activation. In Encyclopedia of Immunology 2nd Ed. (eds. Roitt, I. M. and Delves, P. J.) Academic Press, London.Vol. 1, pp349-352, 1998.
  • Ishii, S., Kuwaki, T., Nagase, T., Maki, K., Tashiro, F., Sunaga, S., Cao, W. H., Kume, K., Fukuchi, Y., Ikuta, K., Miyazaki, J., Kumada, M. and Shimizu, T. : Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor. J. Exp. Med. 187: 1779-88, 1998. (PubMed)
  • Adachi, S., Yoshida, H., Honda, K., Maki, K., Saijo, K., Ikuta, K., Saito, T. and Nishikawa, S. I. : Essential role of IL-7 receptor a in the formation of Peyer's patch anlage. Int. Immunol. 10: 1-7, 1998. (PubMed)
  • Tsuzuki, S., Toyama-Sorimachi, N., Kitamura, F., Tsubio, H., Ando, J., Sakurai, T., Morii, N., Narumiya, S. and Miyasaka, M. : Analysis of Intracellular signal-transducing elements involved in transendothelial migration of lymphoma cells. Jpn. J. Cancer Res. 89: 571-577, 1998. (PubMed)
  • Tsuzuki, S., Toyama-Sorimachi, N., Kitamura, F. and Miyasaka, M. : FK506 (tacrolimus)inhibits wxtravasation of lymphoid cells by abrogating VLA-4/VCAM-1 mediated transendothelialmigration.FEBSLett. 430: 414-418, 1998. (PubMed)
  • Minegishi, Y., Coustan-Smith, E., Wang, Y.H., Cooper, M.D., Campana, D., Conley, M.E. Mutations in the human _5/14.1 gene result in B cell deficiency and agammaglobulinemia. J. Exp. Med. 187, 71-77, 1998. (PubMed)
  • Conley, M.E., Mathias, D., Treadaway, J., Minegishi, Y., Rohrer, J. Mutations in Btk in patients with presumed X-linked agammaglobulinemia. Am. J. Hum. Genet. 62, 1034-1043, 1998. (PubMed)
  • Nagata, K., Nakamura, T., Kitamura, F., Kuramochi, S., Taki, S., Campbell, K. S. and Karasuyama, H.: The Ig?/Ig? heterodimer on ?-negative proB cells is competent for transducing signals to induce early B cell differentiation. Immunity 7: 559-570, 1997. (PubMed)
  • Kuramochi, S. Moriguchi, T., Kuida, K., Endo, J., Semba, K., Nishida, E. and Karasuyama, H.: LOK, a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes. In Kinases and phosphatases in lymphocyte and neuronal signaling (eds. Yakura, H.) Springer-Verlag. pp354, 1997.
  • Koyama, M., Ishihara, K., Karasuyama, H., Cordell, J. L., Iwamoto, A., and Nakamura, T. CD79a/CD79b heterodimers are expressed on pro-B cell surfaces without associated ? heavy chain. Int. Immunol. 9: 1767-1772, 1997. (PubMed)
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  • Emoto, K., Toyama-Sorimachi, N., Karasuyama, H., Inoue, K. and Umeda M.: Exposure of phosphatidylethanolamine of the surface of apoptotic cells. Exp. Cell Research 232: 430-434, 1997. (PubMed)
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