Hajime Karasuyama

1972 - 1978 Tokyo Medical and Dental University School of Medicine MD. 1978.
1978 - 1980 Internship at Tsukuba University Hospital
1980 - 1984 Postgraduate, Department of Immunology, Faculty of Medicine,
University of Tokyo PhD. 1984.
1984 - 1987 Scientific member, Basel Institute for Immunology, Basel, Switzerland
1987 - 1990 Research Associate, Department of Immunology, Faculty of Medicine,
University of Tokyo
1990 - 1995 Scientific member, Basel Institute for Immunology, Basel, Switzerland
1995 - 2000 Head, Department of Immunology,
The Tokyo Metropolitan Institute of Medical Science
2000 - present Professor, Department of Immune Regulation
Tokyo Medical and Dental University, Graduate School

Main publications

  • Karasuyama, H., Wada, T., Yoshikawa, S., and Obata, K.: Emerging roles of basophils in protective immunity against parasites. Trends Immunol . 32: 125-130, 2011. (PubMed)
  • Karasuyama, H., Mukai, K., Obata, K., Tsujimura, Y., and Wada, T.: Nonredundant roles of basophils in immunity. Annu. Rev. Immunol . 29: 45-69, 2011. (PubMed)
  • Saito, M., Nagasawa, M., Takada, H., Hara, T., Tsuchiya, S., Agematsu, K., Yamada, M., Kawamura, N., Ariga, T., Tsuge, I., Nonoyama, S., Karasuyama, H ., and Minegishi, Y.: Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells. J. Exp. Med . 208: 235-249, 2011. (PubMed)
  • Wada, T., Ishiwata, K., Koseki, H., Ishikura, T., Ugajin, T., Ohnuma, N., Obata, K., Ishikawa, R., Yoshikawa, S., Mukai, K., Kawano, Y., Minegishi, Y., Yokozeki, H., Watanabe, N., and Karasuyama, H.: Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J. Clin. Invest . 120: 2867-2875, 2010. (PubMed).
  • Minegishi, Y., Saito, M., Nagasawa, M., Takada, H., Hara, T., Tsuchiya, S., Agematsu, K., Yamada, M., Kawamura, N., Ariga, T., Tsuge, I., and Karasuyama, H .: Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome. J. Exp. Med . 206: 1291-1301, 2009. (PubMed).
  • Karasuyama, H., Mukai, K., Tsujimura, Y. and Obata, K.: Newly-discovered roles for basophils: a neglected minority gains new respect. Nat. Rev. Immunol . 9: 9-13, 2009. (PubMed).
  • Tsujimura, Y., Obata, K., Mukai, K., Shindou, H., Yoshida, M., Nishikado, H., Kawano, Y., Minegishi, Y., Shimizu, T. and Karasuyama, H .: Basophils play a pivotal role in immunoglobulin G- but not immunoglobulin E-mediated systemic anaphylaxis. Immunity 28: 581-589, 2008 (PubMed).
  • Minegishi, Y., Saito, M., Tsuchiya, S., Tsuge, I., Takada, H., Hara T., Kawamura, N., Ariga, T., Pasic, S., Stojkovic, O., Metin, A., and Karasuyama, H .: Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Nature 448: 1058-1062, 2007 (PubMed).
  • Minegishi, Y., Saito, M., Morio, T., Watanabe, K., Agematsu, K., Tsuchiya, S., Takada, H., Hara, T., Kawamura, N., Ariga, T., Kaneko, H., Kondo, N., Tsuge, T., Yachie, A., Sakiyama, Y., Iwata, T., Bessho, F., Ohishi, T., Joh, K., Imai, K., Kogawa, K., Shinohara, M., Fujieda, M., Wakiguchi, H., Pasic, S., Abinun, M., Ochs, H., D., Renner, E., D., Jansson, A., Belohradsky, B., H., Metin, A., Shimizu, N., Mizutani, S., Miyawaki, T., Nonoyama, S., and Karasuyama, H.: Human Tyk2 deficiency reveals requisite roles of Tyk2 in multiple cytokine signals involved in innate and acquired immunity.Immunity 25: 745-755, 2006(PubMed)
  • Mukai, K., Matsuoka, K., Taya, C., Suzuki, H., Yokozeki, H., Nishioka, K., Hirokawa, K., Etori, M., Yamashita, M., Kubota, T., Minegishi, Y., Yonekawa, H., and Karasuyama, H.: Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity 23: 191-202, 2005 (PubMed)
  • Toyama-Sorimachi, N., Tsujimura, Y., Maruya,M., Onoda, A., Kubota, T., Koyasu, S., Inaba, K. and Karasuyama, H.: Ly49Q, a novel member of Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture. Proc. Natl. Acad. Sci. USA. 101: 1016-1021, 2004 (PubMed)
  • Saijo, K., Schmedt, C., Su, I-h., Karasuyama, H., Lowell, C.A., Reth, M., Adachi, T., Patke, A., Santana, A. and Tarakhovsky, A.: Essential role of Src-family protein tyrosine kinases in NF-kB activation during B cell development. Nature Immunol. 4: 274-279, 2003. (PubMed)
  • Kubo, S., Matsuoka, K., Taya, C., Kitamura, F., Takai, T., Yonekawa, H. and Karasuyama, H.: Drastic up-regulation of high affinity IgE receptor on mast cells is induced by IgE binding through stabilization and accumulation of the receptor on the cell surface. J. Immunol. 167: 3427-34, 2001. (PubMed)
  • Toyama-Sorimachi, N., Taguchi, Y., Yagita, H., Kitamura, F., Kawasaki, A., Koyasu, S. and Karasuyama, H.: Mouse CD94 participates in Qa-1-mediated self recognition by NK cells and delivers inhibitory signals independent of Ly-49. J. Immunol. 166: 3771-9, 2001. (PubMed)
  • Maki, K., Nagata, K., Kitamura, F., Takemori, T. and Karasuyama, H.: Immunoglobulin b signaling regulates locus accessibility for ordered Ig gene rearrangements. J. Exp. Med. 191: 1333-1340, 2000. (PubMed)
  • Matsuoka, K., Taya, C., Kubo, S., Toyama-Sorimachi, N., Kitamura, F., Ra, C., Yonekawa, H. and Karasuyama, H.: Establishment of antigen-specific IgE transgenic mice to study pathological and immunobiological roles of IgE in vivo. Int. Immunol. 11: 987-994, 1999. (PubMed)
  • Tsuganezawa, K., Kiyokawa, N., Matsuo, Y., Kitamura, F., Toyama-Sorimachi, N., Kuida, K., Fujimoto, J. and Karasuyama, H.: Flow cytometric diagnosis of the cell lineage and developmental stage of acute lymphoblastic leukemia by novel monoclonal antibodies specific to human preB cell receptor. Blood 92: 4317-4324, 1998. (PubMed)
  • Kuida, K., Haydar, T. F., Kuan, C-Y., Gu, Y., Taya, C., Karasuyama, H., Su, M. S.-S., Rakic, P. and Flavell, R. A.: Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94: 325-337, 1998. (PubMed)
  • Nagata, K., Nakamura, T., Kitamura, F., Kuramochi, S., Taki, S., Campbell, K. S. and Karasuyama, H: The Iga/Igb heterodimer on m-negative proB cells is competent for transducing signals to induce early B cell differentiation. Immunity 7: 559-570, 1997. (PubMed)
  • Kuramochi, S., Moriguchi, T., Kuida, K., Endo, J., Semba, K., Nishida, E. and Karasuyama, H.: LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes. J. Biol. Chem. 272: 22679-22684, 1997. (PubMed)
  • Kuida, K., Zheng, T. S., Na, S., Kuan C., Yang, D., Karasuyama, H, Rakic, P. and Flavell, R. A.: Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384: 368-372, 1996. (PubMed)
  • Karasuyama, H, Rolink, A. and Melchers, F.: Surrogate light chain in B cell development. Adv. Immunol. 63: 1-41, 1996. (PubMed)
  • Karasuyama, H, Rolink, A., Shinkai, Y., Young, F., Alt, F. W., and Melchers, F. : The expression of VpreB/l5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice. Cell 77: 133-143, 1994. (PubMed)
  • Karasuyama, H, Rolink, A., and Melchers, F.: A complex of glycoproteins is associated with VpreB/ l5 surrogate light chain on the surface of m heavy chain-negative early precursor B cell lines. J. Exp. Med. 178: 469-478, 1993. (PubMed)
  • Golumbek, P. T., Lazenby, A. J., Levitsky, H. I., Jaffee, L. H., Karasuyama, H., Baker, M. and Pardoll, D.: Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4. Science 254: 713-716, 1991. (PubMed)
  • Rolink, A., Kudo, A., Karasuyama, H., Kikuchi, Y. and Melchers, F.: Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells "in vitro" and "in vivo". EMBO J. 10: 327-336, 1991. (PubMed)
  • Karasuyama, H., Kudo, A. and Melchers, F.: The proteins encoded by the VpreB and l5 pre-B cell-specific genes can associate with each other and with m heavy chain. J. Exp. Med. 172: 969-972, 1990. (PubMed)
  • Fearon, E. R., Pardoll, D. M., Itaya, T., Golumbek, P., Levitsky, H. I., Simons, J. W., Karasuyama, H., Vogelstein, B. and Frost, P.: Interleukin-2 production by tumor cells bypasses T helper function in the generation of an anti-tumor response. Cell 60: 397-403, 1990. (PubMed)
  • Tohyama, N., Karasuyama, H. and Tada, T.: Growth autonomy and tumorigenicity of interleukin-6 dependent cells transfected with IL-6 cDNA. J. Exp. Med. 171: 389-400, 1990. (PubMed)
  • Karasuyama, H., Tohyama, N. and Tada, T.: Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene. J. Exp. Med. 169: 13-25, 1989. (PubMed)
  • Karasuyama, H., Rolink, A. and Melchers, F.: Recombinant interleukin 2 or 5, but not 3 or 4 induces maturation of resting mouse B lymphocytes and propagates proliferation of activated B cell blasts. J. Exp. Med. 167: 1377-1390, 1988. (PubMed)
  • Staerz, U. D., Karasuyama, H. and Garner, A. M.: Cytotoxic T lymphocytes against a soluble protein. Nature 329: 449-451, 1987. (PubMed)